Early Access Product: Optical Mapping Analysis Platform: Nautilus Enables Calcium Measurement, Action Potential, and More

Curi Bio's Nautilus enables high-throughput analysis of electrophysiology and calcium transients all on a standard SBS-compliant plate.

Information-rich Output Enables Multiple Applications:

  • Calcium Flux
  • Cardiomyocyte Screening
  • Cardiotoxicity
  • Potassium Assays
  • Ion Channel

Prolongation of Action Potential in Human Atrial iPSC Cardiomyocytes

By detecting the mechanics of disease conditions in muscles, Nautilus enables high-throughput screening and discovery applications. Here, Nautilus accurately detected conduction arrhythmias in human atrial hiPSC-CMs by measuring the prolongation and triangulation of Action Potential (AP) in response to E-4031 compound.

Baseline-Human Atrial hiPSC-CMs    Human Atrial hiPSC-CMs (E-4031=hERG blocker)

Positive Inotropic & Chronotropic Responses to Isoproterenol

Intracellular Calcium optical mapping of iPSC-cardiomyocytes using Nautilus instrument provides predictive response to Isoproterenol.

Enables Detection of Dose Response Toxicity 

Voltage Optical Mapping of iPSC-CMs: Pentamidine, an antiprotozoal agent, has been traditionally known to cause QT prolongation and arrhythmias. Here, we are showing the dose response cardiotoxicity of Pentamidine in human atrial iPSC cardiomyocytes using the Nautilus optical mapping instrument. 

Coming Soon!: Nautilus Appplications with 3D EHTs

Read the publication:

Nature Scientific Reports

Human Perinatal Stem Cell Derived Extracellular Matrix Enables Rapid Maturation of hiPSC-CM Structural and Functional Phenotypes

Authors: Travis Block, Jeffery Creech, Andre Monteiro da Rocha, Milos Marinkovic, Daniela Ponce-Balbuena, Eric N. Jiménez-Vázquez, Sy Griffey, and Todd J. Herron

Interested in utilizing Nautilus for your projects?

If you are interested in learning more about how Nautilus can benefit your research, please contact us to arrange a conversation with our team of experts.