CuriBio

  • Curi Bio Nautilus: Optical Mapping of Voltage and Calcium for Clinically-Relevant Screening and Discovery

    Curi Bio Nautilus: Optical Mapping of Voltage and Calcium for Clinically-Relevant Screening and Discovery

    Early Access Product: Optical Mapping Analysis Platform: Nautilus Enables Calcium Measurement, Action Potential, and More

    Curi Bio's Nautilusenables high-throughput analysis of electrophysiology and calcium transients all on a standard SBS-compliant plate.

  • Curi Bio Mantarray: A Platform for Human-Relevant 3D Engineered Muscle Tissue Analysis

    Curi Bio Mantarray: A Platform for Human-Relevant 3D Engineered Muscle Tissue Analysis

    The Curi Bio Mantarray platform enables the discovery, safety, and efficacy testing of new therapeutics by providing parallel analysis of 3D engineered muscle tissues with adult-like functional profiles. Mantarray brings clinically-relevant functional data into the earliest stages of preclinical testing of new medicines.

    Features

    • High-throughput compatible, label-free, non-optical measurement
    • Clinically-relevant functional measurements of contractility
    • Easy tissue casting, measurement, and data analysis (No Matlab, All GUI)
    • Structurally and functionally mature 3D engineered muscle tissues
    • Compatible with electrical stimulation for advanced tissue maturation

    Application

    Disease Modeling & Therapeutic Discovery

    Modeling Duchenne Muscular Dystrophy (DMD) with iPSC-derived EHTs

    Complex diseases require complex models. EMTs can be made from cells sourced from patients and used to test whether a new therapy will improve or recover healthy contraction. 3D Engineered Heart Tissues (EHTs) can be generated from human iPSC-derived cells with healthy and diseased phenotypes.

    Multi-modal Mantarray Data Exhibit Disease Stratification

    Isogenic controls or corrected cell lines can be used to provide clear stratification between healthy and diseased phenotypes. Stratifying differences between healthy disease model EHTs provides a platform for discovery and validation of new therapeutics. Validate new therapies using human models of muscle contractility.

    Application

    Safety Screening

    Magnetic Detection of Drug-induced Contractile Changes

    The magnetic detection approach can measure both acute (minutes) and chronic (days) drug responses. Drugs such as isoproterenol (left) can be measured on the order of seconds to minutes, with enough sensitivity to measure dose response-like behavior. Additionally, longer-term chronic experiments such as doxorubicin (right) can be performed over the course of days.

    How It Works

    The Mantarray system features a novel magnetic sensing technique that can detect the contraction of EMTs. This enables the user to measure the contractility of 24 tissues in parallel, a high throughput, and in real time. The system features user-friendly software that takes away the requirement for manual calculations of contractility, delivering contractility data at the click of a mouse.

    The Mantarray system uses ANSI/SLAS compliant tissue casting devices that can be performed manually or via automation. EMTs can be used in nearly any kind of assay, including force (contractility), calcium, and structural assays. Mantarray brings EMTs into your own lab, allowing you to use your own cells to achieve your research goals.

    Early Access Product

    Curi Bio's Mantarray System: 

    Bring 3D Engineered Heart Tissues into Your Laboratory

    Be among the first to receive an instrument. Learn more today. 

    Download Mantarray brochure here

  • Curi Bio at Device Connect Series: The Next Generation of Life Science Tools

    Curi Bio at Device Connect Series: The Next Generation of Life Science Tools

    On May 13, 2021, Curi Bio’s CSO, Dr. Nicholas Geisse, was a panelist for Device Connect by Life Science Washington hosted by Product Creation Studio.

    Moderated by Sean MacLeod, CEO of FenoLogica Biosciences, the full panelist line-up included:

    We wanted to share the great discussion here for anyone who missed. Enjoy!

    About Device Connect

    Over the past year, the entire world has been focused on medical technologies associated with COVID: diagnostics, vaccines, and drugs. The top medical minds from our state have been front-runners in these discoveries. With these rapid breakthroughs in the spotlight, it’s easy to overlook the tools used to create these types of technologies in the first place. Washington State has long been a leader in the development of life science tools that enable breakthrough discovery. We have a rich and deep history leading the way in oncology, genomics, proteomics, and synthetic biology. In this DeviceConnect, we’ll talk to active members and leaders in our region’s life science tools industry. Gain insight into the ground that’s been covered, and what breakthroughs are on the horizon.

    Image: Curi Bio 96-well NanoSurface plate

     

  • Recapitulate the Extracellular Matrix in a Dish with Curi Bio NanoSurface Biomimetic Technology: Buy 5 Get 5 Free for March

    Recapitulate the Extracellular Matrix in a Dish with Curi Bio NanoSurface Biomimetic Technology: Buy 5 Get 5 Free for March

    Curi Bio NanoSurface Plates provide your cells and tissues a biomimetic surface to improve the physiological relevance of your experiments. Shortly after plating, cells cultured on NanoSurface Plates exhibit enhanced structural and phenotypic development when compared to cells grown on conventional dishes. NanoSurface topography promotes cytoskeletal reorganization and cellular alignment by mimicking the structure of the extracellular matrix. NanoSurface Plates are available in familiar standard formats, featuring glass-bottom wells for high-quality imaging.

    NanoSurface dishes promote the structural and phenotypic development of many cell types:

    • Cardiomyocytes
    • Fibroblasts
    • Induced pluripotent stem cells
    • Epithelial cells
    • Human embryonic stem cells
    • Smooth muscle cells
    • Endothelial cells
    • Cancer cells
    • Mesenchymal stem cells
    • Neuronal cells
    • Skeletal muscle cells

    March 2021 Promo: Buy 5 384-WELL Nanosurface plates and get 5 free. Offer valid through March 2021

    Download Nanosurface Plates Product Brochure here

    Download Nanosurface Plates Technical Datasheet here

    Learn more about Curi Bio Nanosurface Plates here.

    Product Specifications

    Note: All numbers are approximate and subject to revision.
    Product Code ANFS-0384 
    Surface Topography NanoSurface
    Well Dimension 3.00 x 11.50 mm
    Approx. Pattern Growth Area 8.1 mm2
    Working Volume 15 – 110 µL
    Total Well Volume 133 µL
    Dimensions 127.76 L x 85.48 W x 16.90 H mm
    Packaging Volume 5 Plates
    Cell Culture Treated Yes
    Sterilized with Gamma Irradiation Yes
    ANSI/SLAS Microplate Size Compliant Yes

     

  • Curi Bio ComboMat: Mature Your Human iPSC-CMs with Curi's Proprietary Maturation Platform for Cardiomyocytes

    Curi Bio ComboMat: Mature Your Human iPSC-CMs with Curi's Proprietary Maturation Platform for Cardiomyocytes

    ComboMat combines proprietary maturational cues to enhance iPSC-CM maturity.

    CuriBio's ComboMat is a combinatorial maturation platform that leverages NanoSurface™ Technology, media factors, and a gene expression-regulating microRNA (miR) formula to synergistically advance the maturation of hiPSC-CMs. ComboMat treated cardiomyocytes exhibit enhanced structural, functional, electrophysiological, and metabolic development.

    ComboMat Includes a Proprietary Cocktail of microRNAs

    The proprietary miR formula included in the ComboMat protocol specifically targets key pathways that drive cardiac-specific functional development, and can be applied to any hiPSC-CM cell line. ComboMat treated cells result in more human adult-like structural, functional, metabolic, and functional maturation.

     

    Key Characteristics

    ComboMat Drives iPSC-CM Maturation and Functional Development

    • Structure - Increased sarcomere length and width, cell area, and more physiological cell aspect ratio.

    • Electrophysiology - Exhibit longer field potential durations as measured by MEA, and lower resting beat rates than control iPSC-CMs.

    • Metabolism - Enhanced metabolic developmental profiles, including a switch from glucose metabolism to fatty acid metabolism.

    • Function - Generate more contractile force than control iPSC-CMs.

    Application

    Enable Predictive Safety Screening

    ComboMat hiPSC-CMs are able to accurately predict the cardiotoxicity of known high-risk drugs such as Bepridil, which the same untreated hiPSC-CMs fail to do so. In an MEA-based electrophysiology study, iPSC-CMs treated with 1 µM Bepridil exhibited clear EAD arrhythmic events in LEAP signals.

    Application

    Enable Creation of Well-Stratified Models of Human Disease

    Phenotypic stratification of disease models provides a platform for the discovery and efficacy screening of new therapeutics.

    Metabolic Disease

    ComboMat drives iPSC-CMs toward the ability to metabolize fatty acids, a hallmark of metabolic maturity in adult cardiomyocytes. In a model of mitochondrial trifunctional protein deficiency, wild type ComboMat iPSC-CMs showed an enhanced ability to metabolize fatty acids in a SeaHorse palmitate assay, while both ComboMat mutant iPSC-CMs and wild type iPSC-CMs that did not receive ComboMat treatment did not. Only cell models that received ComboMat treatment were able to stratify the healthy metabolic phenotype from the disease phenotypes. ComboMat mutant cells exhibited proton leak, a phenotype that was rescued after treatment with SS-31 (Elamipretide).

     

    Duchenne Muscular Dystrophy (DMD) Associated Cardiomyopathy

    In a ComboMat iPSC-CM model of DMD Associated Cardiomyopathy, DMD mutant iPSC-CMs showed significantly higher cytosolic Ca2+ levels and significantly higher beat rate variability than wild type iPSC-CMs. DMD mutant and wild type iPSC-CMs that did not receive ComboMat treatment failed to show stratification of these key disease phenotypes. Treatment with Sildinafil failed to rescue the proarrhythmic phenotype, matching known clinical results.
     
     
     
     

    Read papers on ComboMat:

    TFPa/HADHA is Required for Fatty Acid Beta-oxidation and Cardiolipin Re-modeling in Human Cardiomyocytes – Miklas et al.

    Published in Nature Communications

     

    Engineered Developmental Niche Enables Predictive Phenotypic Screening in Human Dystrophic Cardiomyopathy – Macadangdang et al.

    Available on BioRxiv

     

     

     

  • NanoSurface Biomedical is now CuriBio

    NanoSurface Biomedical is now CuriBio

    Nanoscale Biomedical has recently changed its name, and is now known as: Curi Bio. 

    Curi Biois integrating human iPSC-derived cells, tissue-specific biosystems, and AI-enabled data analytics to accelerate the discovery of new therapeutics.

    For example Curi Bio offer Nanosurface Plates, a versatile platform for creating structured cell and tissue models. NanoSurface Plates feature a biomimetic nanopatterned surface to enhance the structural development of cells and tissues and improve the physiological relevance of cell-based assays. Cells cultured on NanoSurface Plates exhibit enhanced structural and phenotypic development. NanoSurface topography promotes cytoskeletal reorganization, cellular alignment, and functional development of a variety cell types, including iPSC-derived cardiomyocytes, skeletal muscle, and neuronal cells.

    Key Features of NanoSurface Plates

    • Biomimetic Technology
    • Nanoscale topography mimics the aligned architecture and spatial scale of the native extracellular matrix.
    • Reproducibly Structured Cell Cultures
    • NanoSurface plates promote the structural alignment and development of adherent mammalian cells, improving reproducibility and physiological relevance.
    • High-Quality Imaging
    • NanoSurface Plates are compatible with high-magnification, high-NA transmitted light and fluorescence microscopy techniques. No spectral loss across commonly used fluorophores.
    • Industry-Standard Plate Formats
    • NanoSurface Plates are ANSI/SLAS-compliant to guarantee compatibility with existing instrumentation and workflows.
  • Curi Bio Cytostretcher

    Curi Bio Cytostretcher

    The Curi Bio Cytostretcher family of instruments is a powerful and easy-to-use integrated solution for cell mechanics research. The Cytostretcher and Cytostretcher-LV empower you to gain new insights into the relationship between the cell and its microenvironment—important for nearly all mammalian cell types. NanoSurface’s patterning technology provides structural cues that recapitulate the native ECM within flexible stretching chambers. The included NaOMI software provides total experimental control in a clean, intuitive interface. With the NanoSurface Cytostretcher, you can image live cells during your stretch routines. The Cytostretcher-LV and Cytostretcher Chambers are compatible with transmitted light and high-NA fluorescence microscopy, including immersion objectives.

    NanoSurface Cytostretcher Benefits

    Flexible Software Allows for Unprecedented Experimental Control 

    NaOMI – the NanoSurface Operational Mechanics Interface allows for intuitive control of stretching routines and protocols for NanoSurface Cytostretcher instruments. Learn more about NaOMI on this page.

    Compact Design 

    The Cytostretcher is extremely compact, easily integrating into your existing cell culture workflow. It can be operated on the bench-top or alongside other cultures inside a standard cell culture incubator – saving valuable space. 

    Run Multiple Experiments in Parallel 

    Flexible Cytostretcher Chambers are available in a variety of formats, so you can mechanically condition many cultures in parallel. Larger chambers offer more culture area (up to 25 cm2). Smaller chambers offer higher throughput (up to 24 wells). 

    Convenient Control Unit 

    The Cytostretcher Control Unit is a small, lightweight module that can be magnetically attached to the exterior of a cell culture incubator. 

    NanoSurface Cytostretcher Brochure

    Download the NanoSurface Cytostretcher product brochure for general information about NanoSurface Cytostretcher and Cytostretcher-LV products in a convenient PDF format. 

    Download Brochure here:

    Understand the Effects of Mechanical and Microenvironmental Cues 

    The NanoSurface Cytostretcher allows researchers to investigate both tissue-level mechanical strain and microenvironmental cues at the same time. 

    The Cytostretcher family of instruments is a powerful and easy-to-use integrated solution for cell mechanics research. The Cytostretcher and Cytostretcher-LV empower you to gain new insights into the relationship between the cell and its microenvironment – important for nearly all mammalian cell types. NanoSurface’s patterning technology provides structural cues that recapitulate the native ECM within flexible stretching chambers. The included NaOMI software provides total experimental control in a clean, intuitive interface. 

    The flexibility and power of the Cytostretcher family of instruments ensures that every cell stretching experiment can be implemented with ease and precision. 

    Nanopatterned or Flat Stretch Chambers 

    Cytostretcher Chambers are available with either NanoSurface topography that mimics the aligned architecture of the native extracellular niche or with traditional unpatterned “flat” surfaces. Patterned chambers feature topography either aligned in parallel or perpendicular to the direction of applied stretch. NanoSurface topography promotes the development of physiologically-relevant structures and phenotypes in many cell types: 

     

    The NanoSurface Cytostretcher allows researchers to investigate both tissue-level mechanical strain and microenvironmental cues at the same time.

    Cytostretcher Chambers are available with either NanoSurface topography that mimics the aligned architecture of the native extracellular niche or with traditional unpatterned “flat” surfaces. Patterned chambers feature topography either aligned in parallel or perpendicular to the direction of the applied stretch. NanoSurface topography promotes the development of physiologically-relevant structures and phenotypes in many cell types:

     

    • Skeletal muscle cells
    • Smooth muscle cells
    • Neuronal cells
    • Cardiomyocytes
    • Endothelial cells
    • Epithelial cells
    • Fibroblasts
    • Cancer cells
    • Induced pluripotent stem cells
    • Mesenchymal stem cells
    • Human embryonic stem cells
    • And many more
  • Curi Bio Cytostretcher

    Curi Bio Cytostretcher

    The Curi Bio Cytostretcher family of instruments is a powerful and easy-to-use integrated solution for cell mechanics research. The Cytostretcher and Cytostretcher-LV empower you to gain new insights into the relationship between the cell and its microenvironment—important for nearly all mammalian cell types. NanoSurface’s patterning technology provides structural cues that recapitulate the native ECM within flexible stretching chambers. The included NaOMI software provides total experimental control in a clean, intuitive interface. With the NanoSurface Cytostretcher, you can image live cells during your stretch routines. The Cytostretcher-LV and Cytostretcher Chambers are compatible with transmitted light and high-NA fluorescence microscopy, including immersion objectives.

    NanoSurface Cytostretcher Benefits

    Flexible Software Allows for Unprecedented Experimental Control 

    NaOMI – the NanoSurface Operational Mechanics Interface allows for intuitive control of stretching routines and protocols for NanoSurface Cytostretcher instruments. Learn more about NaOMI on this page.

    Compact Design 

    The Cytostretcher is extremely compact, easily integrating into your existing cell culture workflow. It can be operated on the bench-top or alongside other cultures inside a standard cell culture incubator – saving valuable space. 

    Run Multiple Experiments in Parallel 

    Flexible Cytostretcher Chambers are available in a variety of formats, so you can mechanically condition many cultures in parallel. Larger chambers offer more culture area (up to 25 cm2). Smaller chambers offer higher throughput (up to 24 wells). 

    Convenient Control Unit 

    The Cytostretcher Control Unit is a small, lightweight module that can be magnetically attached to the exterior of a cell culture incubator. 

    NanoSurface Cytostretcher Brochure

    Download the NanoSurface Cytostretcher product brochure for general information about NanoSurface Cytostretcher and Cytostretcher-LV products in a convenient PDF format. 

    Download Brochure here:

    Understand the Effects of Mechanical and Microenvironmental Cues 

    The NanoSurface Cytostretcher allows researchers to investigate both tissue-level mechanical strain and microenvironmental cues at the same time. 

    The Cytostretcher family of instruments is a powerful and easy-to-use integrated solution for cell mechanics research. The Cytostretcher and Cytostretcher-LV empower you to gain new insights into the relationship between the cell and its microenvironment – important for nearly all mammalian cell types. NanoSurface’s patterning technology provides structural cues that recapitulate the native ECM within flexible stretching chambers. The included NaOMI software provides total experimental control in a clean, intuitive interface. 

    The flexibility and power of the Cytostretcher family of instruments ensures that every cell stretching experiment can be implemented with ease and precision. 

    Nanopatterned or Flat Stretch Chambers 

    Cytostretcher Chambers are available with either NanoSurface topography that mimics the aligned architecture of the native extracellular niche or with traditional unpatterned “flat” surfaces. Patterned chambers feature topography either aligned in parallel or perpendicular to the direction of applied stretch. NanoSurface topography promotes the development of physiologically-relevant structures and phenotypes in many cell types: 

     

    The NanoSurface Cytostretcher allows researchers to investigate both tissue-level mechanical strain and microenvironmental cues at the same time.

    Cytostretcher Chambers are available with either NanoSurface topography that mimics the aligned architecture of the native extracellular niche or with traditional unpatterned “flat” surfaces. Patterned chambers feature topography either aligned in parallel or perpendicular to the direction of the applied stretch. NanoSurface topography promotes the development of physiologically-relevant structures and phenotypes in many cell types:

     

    • Skeletal muscle cells
    • Smooth muscle cells
    • Neuronal cells
    • Cardiomyocytes
    • Endothelial cells
    • Epithelial cells
    • Fibroblasts
    • Cancer cells
    • Induced pluripotent stem cells
    • Mesenchymal stem cells
    • Human embryonic stem cells
    • And many more
  • Curi Bio Cultureware

    Curi Bio Cultureware

    Biomimetic Nanoscale Surface Topography Imitates the Aligned Structure of the Native Extracellular Matrix.

    Curi Bio provides innovative products and services for drug development, disease modeling, and fundamental research into cell biology. NanoSurface technology imitates the native extracellular matrix and structures cultured cells into physiologically relevant models.

    Cells in the Dish Should Resemble Cells in the Body.

    Human iPSC-derived cardiomyocytes cultured in a NanoSurface dish develop structural and functional phenotypes similar to native cardiac tissue. NanoSurface culture is consistent, reproducible, and fast, which is why many scientists rely on NanoSurface technology as a new standard for iPSC-derived cardiomyocyte culture.

    (CDI iCell) Conventional Dish (CDI iCell) NanoSurface Cultureware

    More Mature Cell and Tissue Cultures, Faster

    NanoSurface Cultureware provides your cells and tissues a biomimetic surface to improve the physiological relevance of your experiments. Shortly after plating, cells cultured on NanoSurface Cultureware exhibit enhanced structural and phenotypic development when compared to cells grown on conventional dishes. NanoSurface topography promotes cytoskeletal reorganization, cellular alignment, and functional development. NanoSurface Cultureware is available in familiar standard formats, featuring No. 1.5 glass-bottom wells for high-quality imaging. 

    Download brochure here.

    Benefits of NanoSurface Cultureware

    • High-quality Imaging
    • Compatible with high-magnification, high-NA transmitted light and fluorescence microscopy techniques. No spectral loss across commonly used fluorophores.
    • Reproducibly Structured Cell Cultures
    • Highly uniform, precise, and accurate nanopatterns ensure that your results are consistent from plate to plate.
    • Industry Standard Culture Formats
    • Cultureware comes in a variety of ANSI/SLAS compliant form factors to guarantee compatibility with existing instrumentation and hardware. 
    • Biomimetic Technology
    • Nanoscale topography mimics the aligned architecture of the extracellular matrix. 
    • NanoSurface Dishes Promote the Structural and Phenotypic Development of Many Cell Types

     

    Examples of cells cultures that would benefit with the use of NanoSurface Cultureware:

    • Fibroblasts
    • Cancer cells
    • Induced pluripotent stem cells
    • Mesenchymal stem cells
    • Human embryonic stem cells
    • Skeletal muscle cells
    • Smooth muscle cells
    • Neuronal cells
    • Cardiomyocytes
    • Endothelial cells
    • Epithelial cells
    • And many more

    Conventional Dish

    Conventional cultureware does not utilize biomimetic surface topography, which results in random structural orientation. The disorganized isotropic cell and tissue architectures result in immature functional phenotypes that do not reproduce in vivo function. These inaccuracies lead to imprecise, hard-to-reproduce results and wasted time and effort.

    EA.hy926 Human Endothelial Cells / Conventional EA.hy926 Human Endothelial Cells / NanoSurface

    NanoSurface Cultureware

    NanoSurface Cultureware features a nanopatterned culture surface which provides a cellular microenvironment that mimics the aligned architecture of the native extracellular matrix – improving physiological relevance by promoting development. Cells can align, elongate, grow, and even migrate along the pattern while exhibiting more physiologically representative structural and functional phenotypes. 

    Biomimetic Nanoscale Surface Topography Imitates the Aligned Structure of the Native ECM

    Nanopatterned culture surfaces allow cells to align, elongate, grow, and even migrate along the nanopattern while exhibiting more physiologically representative structural and functional phenotypes.

     

    The underlying matrix of the native myocardium has an aligned architecture (scale bar 10 µm).

    Browse publications list here.

     

  • Curi Bio Biomedical

    Curi Bio Biomedical

    Curi Bio provides innovative products and services for drug development, disease modeling, and fundamental research into cell biology. NanoSurface technology imitates the native extracellular matrix and structures cultured cells into physiologically relevant models.

  • Curi Bio

    Curi Bio

    Curi Bio provides innovative products and services for drug development, disease modeling, and fundamental research into cell biology. NanoSurface technology imitates the native extracellular matrix and structures cultured cells into physiologically relevant models.

    Cells in the Dish Should Resemble Cells in the Body.

    Human iPSC-derived cardiomyocytes cultured in a NanoSurface dish develop structural and functional phenotypes similar to native cardiac tissue. NanoSurface culture is consistent, reproducible, and fast, which is why many scientists rely on NanoSurface technology as a new standard for iPSC-derived cardiomyocyte culture.

    More Mature Cell and Tissue Cultures, Faster

    NanoSurface Cultureware provides your cells and tissues a biomimetic surface to improve the physiological relevance of your experiments. Shortly after plating, cells cultured on NanoSurface Cultureware exhibit enhanced structural and phenotypic development when compared to cells grown on conventional dishes. NanoSurface topography promotes cytoskeletal reorganization, cellular alignment, and functional development. NanoSurface Cultureware is available in familiar standard formats, featuring No. 1.5 glass-bottom wells for high-quality imaging. 

    Benefits of NanoSurface Cultureware

    • High-quality Imaging
    • Compatible with high-magnification, high-NA transmitted light and fluorescence microscopy techniques. No spectral loss across commonly used fluorophores.
    • Reproducibly Structured Cell Cultures
    • Highly uniform, precise, and accurate nanopatterns ensure that your results are consistent from plate to plate.
    • Industry Standard Culture Formats
    • Cultureware comes in a variety of ANSI/SLAS compliant form factors to guarantee compatibility with existing instrumentation and hardware. 
    • Biomimetic Technology
    • Nanoscale topography mimics the aligned architecture of the extracellular matrix. 
    • NanoSurface Dishes Promote the Structural and Phenotypic Development of Many Cell Types

     

    Examples of cells cultures that would benefit with the use of NanoSurface Cultureware:

    • Fibroblasts
    • Cancer cells
    • Induced pluripotent stem cells
    • Mesenchymal stem cells
    • Human embryonic stem cells
    • Skeletal muscle cells
    • Smooth muscle cells
    • Neuronal cells
    • Cardiomyocytes
    • Endothelial cells
    • Epithelial cells
    • And many more

     

    Conventional Dish

    Conventional cultureware does not utilize biomimetic surface topography, which results in random structural orientation. The disorganized isotropic cell and tissue architectures result in immature functional phenotypes that do not reproduce in vivo function. These inaccuracies lead to imprecise, hard-to-reproduce results and wasted time and effort.

    NanoSurface Cultureware

    NanoSurface Cultureware features a nanopatterned culture surface which provides a cellular microenvironment that mimics the aligned architecture of the native extracellular matrix – improving physiological relevance by promoting development. Cells can align, elongate, grow, and even migrate along the pattern while exhibiting more physiologically representative structural and functional phenotypes. 

    Biomimetic Nanoscale Surface Topography Imitates the Aligned Structure of the Native ECM

    Nanopatterned culture surfaces allow cells to align, elongate, grow, and even migrate along the nanopattern while exhibiting more physiologically representative structural and functional phenotypes.

     

    The underlying matrix of the native myocardium has an aligned architecture (scale bar 10 µm).