Abberior fluorophores for superresolution microscopy

20150814 Abberior OverviewMarkers

 

Above: Full listing of available fluorophores from Abberior. Please click on image to open full-size in new window.

Abberior GmbH offers fluorescent dyes and labels that are exceptionally well suited for superresolution microscopy such as STED, GSD, PALM, STORM, GSDIM, SIM, and RESOLFT. They also give outstanding results in confocal and epifluorescence microscopy as well as in single-molecule applications. Our mission is to become the leading supplier for fluorescent labels in superresolution microscopy/nanoscopy.

In recent years, fluorescence microscopy has undergone a revolution: the resolution barrier given by the diffraction limit was broken by new microscopy concepts such as STED, GSD, RESOLFT, PALM, STORM, GSDIM. All of these concepts are based on the proper design and utilization of the photophysical /photochemical properties of the dye. Hence, the dye plays a key role for obtaining the ultrasharp pictures with these methods.

Based on more than a decade of research experience in superresolution microscopy / fluorescence nanoscopy and a passion for developing new, functionalized dyes for this new era of microscopy, the Abberior team is best positioned to offer fluorophore labels for the most demanding, cutting-edge nanoscopy/superresolution applications. Abberior uses patent-protected technology and will continue to invest into the development of new products.

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Fluorophores for Superresolution Microscopy: High Quality Primary Antibodies Conjugated to Abberior Dyes

Tom22 confocal

Vero cells labeled with Anti-Tom22 coupled to Abberior STAR 635P, Abberior STAR 600, Abberior STAR 580, Abberior STAR 440SXP imaged using confocal microscopy.

Abberior is pleased to announce its collaboration with Miltenyi Biotec to offer a custom conjugation of Abberior Dyes to primary antibodies from Miltenyi Biotec. Abberior offers fluorescent dyes and labels that are exceptionally well suited for superresolution microscopy such as STED, GSD, PALM, STORM, GSDIM, SIM, and RESOLFT. They also give outstanding results in confocal and epifluorescence microscopy as well as in single-molecule applications.  Now, in addition, customers can use the conjugation service offered by Miltenyi Biotec to get the primary antibody of choice coupled to any Abberior dye.

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Gattaquant DNA nanotechnology featured in Nature

image manager product images thumbnail dna origami based super resolution for custom nanoruler

Nature recently published a Technology Feature about DNA nanotechnology including the big names of the field from Seeman to Rothemund, Shih, Douglas and many more. So we are very happy that GATTAquant – with the first commercial application of DNA origami worldwide – is mentioned amongst them, citing their CSO Max Scheible:

One popular adornment to nanostructured DNA is light-emitting materials called fluorophores. GATTAquant DNA Nanotechnologies in Braunschweig, Germany, for instance, makes nanorulers from DNA origami structures and fluorescent molecules to validate super-resolution microscopes. Super-resolution microscopy allows researchers to take images beyond the resolution limit set by the diffraction of light, but “there is no standard to measure the resolution of the system,” says Max Scheible, head of research and development at GATTAquant. “DNA nanotechnology really enabled this.”

GATTAquant attaches fluorescent molecules at precise distances on an origami structure and mounts them on glass slides. These nanoscale rulers allow researchers to verify the resolution of sub-diffraction-limit microscopes."

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