Introducing: Abberior Instruments

Lastek is delighted to announce that it has been appointed Asia-Pacific distributor for Abberior Instruments

Co-founded by 2014 Nobel Prize in Chemistry winner, Professor Stefan W. Hell, Abberior aims to become the leading supplier of cutting-edge super-resolution technology with the best possible resolution performance. In combination with their sister company Abberior, they offer an unrivaled combination of superresolution dyes and nanoscopy hardware.

Why work with Abberior Instruments and Lastek?

  • Connect with the inventors of STED and RESOLFT
  • Get the best possible resolution performance
  • Development cycles less than one year: stay cutting-edge with your upgradable system from Abberior Instruments
  • Why buy an outdated confocal/widefield microscope when you can get the latest superresolution technology for the same price?

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Abberior 2-color STED 775 QUAD Scanning

 

Two-color superresolution STED microscope with a pulsed STED laser @ 775 nm

  • Multicolor confocal scanning system with variable pinhole size
  • Detector gating with up to 4 gates
  • Accessible optomechanical design, open electronics and software platform, ready to implement your own imaging ideas
  • Zero-compromize on performance - get the best resolution performance possible in STED microscopy
  • QUAD beam scanner technology
  • We offer unrivaled flexibility in customizing the microscope to your applications

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Abberior 2-color STED 595 QUAD Scanning

 

Two-color superresolution STED microscope with a pulsed STED laser @ 595 nm

  • Multicolor confocal scanning system with variable pinhole size
  • Detector gating with up to 4 gates
  • Accessible optomechanical design, open electronics and software platform, ready to implement your own imaging ideas
  • Zero-compromize on performance - get the best resolution performance possible in STED microscopy
  • QUAD beam scanner technology
  • We offer unrivaled flexibility in customizing the microscope to your applications

We install Your turn-key Abberior 2-color STED 595 QUAD scanning nanoscope in your lab including software/handling training.

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Abberior Instruments 2-color RESOLFT Parallel

Sample: keratin19 (rsCherryRev1.4, red) and vimentin (Dronpa-M159T, green)
Resolution RESOLFT < 80 nm

  • Two superresolution parallel RESOLFT channels: one ‘green channel’ using e.g. rsEGFP or rsEGFP2 and one ‘red channel’ using e.g. rsCherryRev
  • Multicolor widefield system using two sCMOS detectors
  • Accessible optomechanical design, open electronics and software platform, ready to implement your own imaging ideas
  • Zero-compromize on performance - get the best resolution performance possible in RESOLFT microscopy
  • Ultraparallel RESOLFT version using >100.000 donuts
  • We offer unrivaled flexibility in customizing the microscope to your applications

We install your turn-key 2-color parallel RESOLFT nanoscope in your lab including software/handling training.

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Abberior Instruments 1-color STED 775 QUAD Scanning

Abberior Instruments Superresolution STED microscope with a pulsed STED laser @ 775 nm

  • Confocal scanning system
  • QUAD beam scanner technology
  • Detector gating with up to 4 gates
  • Accessible optomechanical design, open electronics and software platform, ready to implement your own imaging ideas
  • Zero compromise on performance - get the best resolution performance possible in STED microscopy

We offer unrivaled flexibility in customizing the microscope to your applications

We install your turn-key Abberior STED 775 QUAD scanning nanoscope in your lab including software/handling training.

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Abberior Instruments 1C RESOLFT QUAD Scanning

Sample: keratin19 (rsCherryRev1.4, red) and vimentin (Dronpa-M159T, green)
Resolution RESOLFT < 80 nm  

One-color superresolution green RESOLFT point scanning system for switchable GFPs

  • Multicolor confocal system with variable pinhole size
  • Accessible optomechanical design, open electronics and software platform, ready to implement your own imaging ideas
  • Zero-compromize on performance - get the best resolution performance possible in RESOLFT microscopy
  • QUAD beam scanner technology
  • We also offer unrivaled flexibility in customizing the microscope to your applications.

We install your turn-key RESOLFT scanning nanoscope in your lab including software/handling training.

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Abberior Quad Scanner

Quad Scanner design with 4 galvo mirrors

Features:

  • Patent protected scanning technology
  • Novel four-mirror design
  • Compact and robust scan head
  • No scan lens required:
  • minimal wavefront distortions
  • Beam alignment by software
  • 4 degrees of freedom: beam
  • position & angle independently addressable 
  • Scan field: > 80 x 80 ?m
  • Line frequency: up to 2 kHz

Abberior Instruments Controlling Platform

Controlling platform for Abberior Instruments microscopes

Abberior software platform Inspector

Microscope control:

  • RESOLFT and STED image acquisition
  • QUAD scanner control
  • Laser timing and data collection for pulse-, pixel-, and line-interleaved multiplexing
  • Control of all motorized components (pinhole, mirrors, flipper, shutters, microscope body
  • Ready to control your own lasers and optomechanics

Image analysis:

  • Analysis toolbox for quantitative microscopy
  • Linear and non-linear (RL) deconvolution algorithms
  • Abberior Patchpanel for synchronized Multi-IO
  • 72 configurable signal connectors
  • 12 connectors for ultrafast signals for laser pulsing and gated detection
  • Typical Abberior configuration leaves 40+ connectors for your custom application

New from Abberior Instruments: RESCue STED!

Fig7 tubu red

Abberior Instruments RESCue STED is a STED imaging mode dedicated to live-cell imaging with saving up to 96% of the light dose without compromising the resolution.  

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Abberior Instruments Protected STED technique enhances resolution and contrast in live-cell STED microscopy

neuron

3D-protected STED imaging of neuron in living brain tissue. 3D-rendering of a 3D-image stack of a living neuron expressing the AC-rsEGFP2 actin label in a hippocampal brain slice. Protected STED was applied with resolution enhancement in the xy and z directions. The image shows a stretch of dendrite with dendritic spines. The stack corresponds to 56 z slices spaced by 80 nm. Scale bar: 1 µm.

Abberior Instruments Protected STED technique has been highlighted in a new January 2016 paper in Nature Photonics. Full paper available for download here.

Coordinate-targeted Fluorescence nanoscopy with multiple off states

Johann G. Danzl*†, Sven C. Sidenstein†, Carola Gregor, Nicolai T. Urban, Peter Ilgen, Stefan Jakobs and Stefan W. Hell*

Nature Photonics: Published Online 18 January 2016 DOI: 10.1038/NPHOTON 2015.266

Abstract: By exploiting a second off state of a reversibly switchable fluorophore, a general approach that can reduce photobleaching and enhance resolution of coordinate-targeted fluorescence nanoscopy has been demonstrated.

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